The CardioSolv Simulation Manager (see this and this), is now up and running on the POD cluster. With the CSM running on this system, you can simultaneously run many cardiac simulations and do post-processing analysis. It’s all handled on the back-end by the queuing system, and run on POD’s top-of-the-line 8-processor machines. These run simulations and analysis as fast as is currently possible.

Typically it would take a lot of learning, reading of manpages and trial and error, to get cardiac simulations up and running on such a powerful resource. We’ve made it easy for you to log in, create your simulation, go get coffee, and have results when you return. You could go set up some expensive and time-consuming animal trials and wet-lab experiments, or you could do a preliminary simulation study from your laptop. Wouldn’t you rather the latter?

When you’re ready to get started, just let us know. +1 (888) 525-2232 or info@cardiosolv.com.

Cardiac simulation can be useful on its own, but it’s especially powerful when paired with animal or tissue models. A simulation model can be set up that is analogous to the experimental model, validated against the experimental model, and used to infer information about the experiment that would be impossible to obtain directly.

For example, using an appropriate ion channel model, it’s possible to investigate individual ionic currents underlying a phenomenon observed in the experiment. Additionally, one can extend an experiment by testing things that are not possible experimentally in the simulation model. For instance, if a shock is applied in the experiment, but one wants to test what would happen if no shock were applied, one could run the shock in the experiment, and run analogous simulations both with and without the shock.

Finally, simulation experiments are not subject to the resolution and field-of-view limitations of electrode or optical transmembrane potential mapping. Therefore, if an interesting phenomenon is observed on the surface of the heart, or is suspected to be occurring within the wall of the heart based on experimental observations, simulations can be used to ‘zoom in’ or examine the depths of the tissue, respectively.

Do you have some experimental data you’d like to know more about? Call us at (888) 525-2232 or send us an email at info@cardiosolv.com to discuss how we can help you better understand your experimental results.

We are really excited about our self-service CardioSolv Simulation Manager (CSM), featured here and here. The CardioSolv Simulation Manager makes it possible to run simulations with a minimal effect on your budget, and we continue to strive to make it easy for you to get up and running quickly using it. We also offer telephone and email support for the CSM if you’d like a hand getting started.

Nonetheless, you may want us to run simulations for you. We’re happy to do that. We’ll meet with you, carefully listen to your project and simulation needs, and advise you on the best way to proceed. We will then run all of the specified simulations, check them, and send them to you securely. We can also set things up for you in the CardioSolv Simulation Manager and let you run further simulations yourself.

If you have any questions or would otherwise like to discuss a project with us (free of charge), please email info@cardiosolv.com or call +1 (888) 525-2232.

Below the cut, you will find the second screencast demo of our web-based simulation creator, manager, and analysis tool. In the video, a stable spiral wave in a monodomain sheet is analyzed using four techniques:

1. Activation Mapping: The activation times of the nodes in the mesh are found
2. Repolarization Mapping: The repolarization times of the nodes in the mesh are found
3. Action Potential Duration (APD) Mapping: These maps display the APDs of the nodes in the mesh, which is just the repolarization times minus the activations times
4. Dominant Frequency Mapping: The power spectra of the nodes are computed and the dominant frequency is shown in a map.

These analyses are done on the back-end, and when run on a cluster many can be computed simultaneously by using multiple compute nodes. It is easy for us to add other types of analysis, should they interest you. What kind of analysis would you like to see added?

For more information on the simulator, manager, or CardioSolv, please contact info@cardiosolv.com or +1 (888) 525-2232.

Note: If you’d like to watch the video in high definition, I recommend expanding it to full-screen mode.
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